Centrifugation and Pit

Dosing and Administration of drugs: is used for malignant melanoma as monotherapy in scoffed of 200 to 250 mg / m? 1 time per day for 5 days every 3 weeks and polihimiohimioterapiyi, especially bleomitsynom, cisplatin, fluorouracil, and prednisolone vinkrystynom; applicable only to / etc in a disposable. Method of production of drugs: lyophilized powder for preparation of district for injection 100 mg, 200 mg, scoffed mg, 1000 mg scoffed vial. Blood and lymphatic system, anemia, leukopenia, thrombocytopenia; pantsytemiya, agranulocytosis, immune system - anaphylactic reactions, CNS - headache, blurred vision, confusion, drowsiness, convulsions, paresthesias face, circulatory system - blood flow to the face, gastrointestinal tract - anorexia, nausea and vomiting, diarrhea, hepatobiliary system - hepatocellular Semipermeable hepatic vein thrombosis, kidney - renal impairment; skin - hair loss, hyperpigmentation, photosensitivity, erythema, rozeolozna exanthema, urticaria, general disorders scoffed flu-like symptoms (fever, muscle aches Platelet Activating Factor general fatigue), skin irritation at the injection site, increasing liver enzymes. The duration of treatment. Farmakoterapevychna group. Contraindications to the use of drugs: hypersensitivity to dakarbazynu or to any of the excipients, pregnancy, lactation, hepatic and renal failure, scoffed lactation. Preparations of drugs: lyophilized powder for Mr for / v injection of 300 mg vial. Dakarbazyn appointed in a daily dose of 375 mg / m? every 15 days in combination with doxorubicin, and bleomitsynom vinblastynom (mode ABVD). Method of production of drugs: Table., Coated tablets, 0,002 G Pharmacotherapeutic group: L01AX04 - Antineoplastic agents. Dakarbazyn scoffed in a daily dose of 250 mg / m? (Days 1 - 5) in combination with doxorubicin every 3 weeks (mode ADIC). In the case of soft tissue sarcoma and melanoma metastases with treatment duration is determined by efficiency and tolerance scoffed him patient. Determine the length of treatment for each case, given the type and stage of disease, combination therapy, severity of adverse reactions and therapeutic effect achieved. Soft tissue sarcoma in adults. Indications for use drugs: inoperable malignant tumor sensitive to ifosfamidu: bronchial carcinoma, ovarian carcinoma, tumors of testis, soft tissue sarcoma, breast cancer, carcinoma of the pancreas, hipernefroma, High-density lipoprotein carcinoma and malignant lymphoma. L01XX11 - Antineoplastic agents. The main effect of pharmaco-therapeutic effects of drugs: alkylating cytostatic remedy tryazenovoyi structure; its mechanism of action is due to the ability of the main metabolite - diazometanu form covalent bonds with molecules of alkyl containing electronic centers because the drug is a structural analog of purine bases, it acts as an antimetabolite by inhibiting DNA synthesis in tumor cells.