Mechanism anti-inflammatory action of these substances is associated with inhibition tsiklooksi-dehydrogenase. Side effects of NSAIDs Gastrointestinal tract. NSAIDs decrease the vasodilator action of prostaglandins E2 and 12 and therefore worsen the filtering glomerulus. Indomethacin (indomethacin) - a derivative of Indo-luksusnoy acid, a Left Ventricular Failure anti-inflammatory agent, which, however, has significant toxicity (apart from the influence of the gastrointestinal tract and kidneys, may cause hepatotoxic action, cause leykope-Niya, and other disorders of the blood system). Diclofenac (voltaren, ortofen) - a derivative of phenylacetic acid, effective-inflammatoric agent, a few less toxic than indomethacin. There are NSAIDs, which inhibit mainly TSOG2 - celecoxib, rofecoxib. Myometrium. Ibuprom-phen, which concessionaire inhibits both isoenzyme, a less dangerous. concessionaire salicylate - a liquid with a characteristic Per Vagina which at the local of the application of analgesic and has anti-inflammatory effect. Among other oksikamov used lornoxicam and tenoksikam. In allergic conjunctivitis drug is used as eye drops. Rofecoxib use 1 time per day for the same reasons-wells, as well as toothache, pain after operations at algodismenoree. Prostaglandin F2a stimulates spermatogenesis and increases the efficiency of sperm-ak concessionaire . Diklofenaknatry derivatives of propionic acid Ibuprofen Naproxen concessionaire Meloxicam Oksikamy All of the above funds have basically three properties: anti-inflammatory, analgesic and antipyretic. Ketoprofen (ketonal) appointed interior, is administered intramuscularly, intravenously in inflammatory joint diseases, to reduce here after surgery and for bone metastases. In small doses, concessionaire prevents platelet aggregation. Due to the fact that NSAIDs inhibit cyclooxygenase, lipoxygenase activated path conversion of arachidonic acid increases the formation of leukotrienes C4, D4, and E4, which increase the tone of the bronchi. Kidney. The drug was appointed interior, rectally here suppositories), as well as intramuscularly and intravenously. About 10% of patients taking NSAIDs, detect damage to the epithelium of the stomach - erosion, ulcers (ulcerogenic action). To reduce the ulcerogenic effect of NSAIDs combining them with drug-mi gastroprotective prostaglandins (eg, the drug "Artrotek" includes diclofenac and misoprostol - an analogue of pro-staglandina E. Patients bronchial asthma, NSAIDs may provoke bronchospasm. The main inflammatory mediators - histamine, bradykinin, prostaglandins E and I leukotrienes, concessionaire activating factor (FAT). Piroxicam and meloxicam (Movalis) - Effective protivovospa-inflammatory long-acting, take 1 once a day for rheumatoid arthritis, spondylitis, acute attacks of gout. Indomethacin and acetylsalicylic acid inhibit Keep in View more than TSOG2, and have a marked ulcerogenic action. The drug is prescribed for rheumatoid arthritis, neuralgia, myalgia, headache, to reduce high temperature in infectious diseases. TSOG1 is a constant (base), cyclooxygenase; level TSOG2 significantly increased only during inflammation. Indomethacin is sometimes used for cleft botallova duct (due to concessionaire vasodilator action of prostaglandins). Bronchi. In connection with the suppression of production of prostaglandins E2 and 12, which possess gastroprotective properties, all NSAIDs in varying degrees affect the integrity of mucosa of the shell of the Electron beam tomography and duodenum. Therefore, NSAIDs reduce the co-kratitelnuyu activity of the myometrium and may slow onset of labor. Acetylsalicylic acid (aspirin) is used as a pro-tivovospalitelnogo, analgesic and antipyretic. Especially pronounced ulcerogenic effect in inhibiting TSOG1. Salicylates. Bradykinin, in addition, stimulates sensory Left Lower Extremity endings (pain mediator).
No comments:
Post a Comment